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PCR detection of HLA-B27

AID HLA B*27 PCR kit – detection of HLA B27 for the differential diagnosis of ankylosing spondylitis (AS)

Detection of homozygous and heterozygous AS-risk alleles

It is well known that there is a close connection between the HLA-B*27 allele and ankylosing spondylitis (AS; synonym: Bechterew’s disease). About 90-95% of all patients suffering from AS are HLA-B*27 positive, with a phenotypic frequency of approx. 7-9% in Caucasians.

Because of this high association with the disease, the typifying of HLA-B*27 is suitable for the differential diagnosis of Spondylitis ankylosans. The other seronegative spondylarthritides are also associated to a high percentage with HLA-B*27.

AID HLA-B*27 Kit enables the detection of risk allele for ankylosing spondylitis.

 

Characteristics

  • Differentiation between homozygous and heterozygous AS-risk allele HLA-B*27
  • PCR with subsequent lineprobe assay
  • Specimen: human DNA isolated from buccal swab, Citrate- or EDTA-blood or biopsy
  • Also suited for direct-PCR from blood
  • Control bands on every strip show correct DNA isolation, amplification and hybridization
  • Results within 4 hours
  • Suited for automated systems
  • Evaluation and documentation with AID Scanning system
  • Art.no.: RDB 2300

 

Reader Systems

AID Scanner