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PCR detection of mycobacterium tuberculosis complex and its resistances against isoniazid and rifampicin

AID TB Modul INH / RIF PCR kit – highly sensitive and specific for resistances against first line drugs of TB

Suitable for culture and clinical specimens

The incidence of multidrug resistant and extremely drug resistant strains of Mycobacterium tuberculosis is a serious threat to worldwide TB control. Multidrug-resistant tuberculosis (MDR-TB) is caused by strains resistant to at least Isoniazid (INH) and Rifampin (RIF), the two most powerful first-line Anti-TB drugs.

Strains, which cause extensively drug-resistant TB (XDR-TB), are not only resistant to INH and RIF but also to at least any Fluoroquinolone (FQ) and one of the second-line injectable drugs Amikacin, Kanamycin and Capreomycin.

Resistant TB is more difficult to treat than drug-susceptible TB, there are stronger adverse effects, therapy is more expensive and the patient is more likely to stay infectious for a longer period of time.

Rapid tests that detect resistances are necessary for early initiation of effective therapy. Culture tests can take several weeks.

Characteristics

  • Detection of Mycobacteria of the Mycobacterium tuberculosis complex and its resistances to Isoniazid and Rifampicin
  • For culture and clinical specimens
  • High sensitivity and specificity for resistances to first line drugs
  • Modular system of the test:
    Module 1: INH/RIF
    Module 2: Aminoglycoside
    Module 3: FQ/EMB
  • Results within 4 hours
  • Suited for automated systems
  • Control bands on every strip shows correct DNA isolation, amplification and hybridization
  • Evaluation and documentation with AID scanner and software
  • Art.no.: RDB 2185

 

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