AID NRAS Kit – Sensitive screening for most frequent BRAF mutations

RDB 2265 BRAF

BRAF is a Serotonin/Threonine protein kinase downstream of KRAS in der MAPK-ERK-signal pathway between EGF receptor and cell nucleus. Somatic mutation of BRAF gene can be found in up to 60% of melanoma biopsy and also in other tumor tissue.

Beside a main mutation V600E with a frequency of 70-90% there are some other, less frequent mutations all result in a permanent ON signal of BRAF and therefor a permanent stimulus for cell proliferation.

AID BRAF Kit enables sensitive screening for most frequent mutations in exon 15 of BRAF gene.

 

 

Characteristics

• Sensitive detection of the most frequent mutations of BRAF gene
  Sensitivity: down to 4% mutation vs WT
• PCR with subsequent lineprobe assay
• Control bands on every strip show correct DNA isolation, amplification and hybridization
• Results within 4 hours
• Suited for automated systems
• Evaluation and documentation with AID Scanning system
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Reader Systems

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